February 24, 2024 12:59 pm

EXCLUSIVE: Moderna has Halted a Trial of a New mRNA Vaccine for Young People After a Suspected Myocarditis Case

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EXCLUSIVE: Moderna has Halted a Trial of a New mRNA Vaccine for Young People After a Suspected Myocarditis Case

By ALEX BERENSON

The case, which occurred in a Phase 1 trial of Moderna’s jab for the Epstein-Barr virus, will only add to the concerns around mRNA biotechnology and heart issues, particularly myocarditis.

Investigators for Moderna today halted an early-stage clinical trial for its mRNA Epstein-Barr virus vaccine in adolescents after a participant in the trial developed a suspected case of myocarditis.

The case “necessitates an immediate suspension of all dosing for ALL adolescents,” an investigator at the company that is supervising the trial for Moderna wrote, adding, “Please confirm understanding and receipt of this urgent communication.”

The trial subjects should continue to be monitored for safety, the investigator wrote. About 150 adolescents are in the trial, along with 272 people aged 18-30.

A person not employed by Moderna, which makes the Spikevax Covid vaccine, provided the email to Unreported Truths.

Moderna did not disclose the trial halt, which occurred before stock markets opened for trading Thursday, to investors. Moderna stock is down about 85 percent from its highs in 2021, as sales of Spikevax lag, but it remains among the most valuable biotechnology companies, with a $30 billion market value.

The Epstein-Barr virus, which causes mononucleosis, is one of Moderna’s leading candidates for new vaccines. The company has told investors it could reach billions of dollars in sales a year.

But the trial halt raises questions for Moderna and mRNA jabs that go far beyond the Epstein-Barr vaccine – officially called mRNA-1189 – alone.

The vaccine uses essentially the same design as Moderna’s Covid shot. Both jabs include a strand of modified mRNA surrounded by a tiny fat globule called a “lipid nanoparticle,” or LNP.

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