Most Healthcare Interventions Tested in Cochrane Reviews Are Not Effective According to High Quality Evidence: A Systematic Review and Meta-Analysis
By Jeremy Howick, Despina Koletsi DDS, P.A.Ioannidis, Dr.Claire Madigan, Nikolaos Pandis, Dr. Martin Loef, Harald Walach, Sebastian Sauer, Jos Kleijnen, Dr. Jadbinder Seehra, Ms. Tess Johnson, Stefan Schmidt
– In this large sample of 1567 interventions studied within Cochrane reviews, effects of most interventions (94%) interventions were not supported by high quality evidence.
– Potential harms of healthcare interventions were measured more rarely than benefits.
– Patients, doctors, and policy makers should consider the lack of high-quality evidence supporting the benefits and harms of many interventions in their decision-making.